[The airways microbial community composition in healthy individuals and bronchial asthma patients].
Identifieur interne : 000190 ( Main/Exploration ); précédent : 000189; suivant : 000191[The airways microbial community composition in healthy individuals and bronchial asthma patients].
Auteurs : S V Fedosenko ; L M Ogorodova ; M A Karnaushkina ; E S Kulikov ; I A Deev ; N A KirillovaSource :
- Vestnik Rossiiskoi akademii meditsinskikh nauk [ 0869-6047 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Appareil respiratoire (microbiologie), Asthme (microbiologie), Asthme (physiopathologie), Bactéries (classification), Bactéries (isolement et purification), Bactéries (pathogénicité), Consortiums microbiens (effets des médicaments et des substances chimiques), Enfant (MeSH), Humains (MeSH), Hyperréactivité bronchique (MeSH), Interactions microbiennes (MeSH), Microbiote (physiologie), Résistance bactérienne aux médicaments (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Consortiums microbiens.
- isolement et purification : Bactéries.
- microbiologie : Appareil respiratoire, Asthme.
- pathogénicité : Bactéries.
- physiologie : Microbiote.
- physiopathologie : Asthme.
- classification : Adulte, Bactéries, Enfant, Humains, Hyperréactivité bronchique, Interactions microbiennes, Résistance bactérienne aux médicaments.
English descriptors
- KwdEn :
- Adult (MeSH), Asthma (microbiology), Asthma (physiopathology), Bacteria (classification), Bacteria (isolation & purification), Bacteria (pathogenicity), Bronchial Hyperreactivity (MeSH), Child (MeSH), Drug Resistance, Bacterial (MeSH), Humans (MeSH), Microbial Consortia (drug effects), Microbial Interactions (MeSH), Microbiota (physiology), Respiratory System (microbiology).
- MESH :
- classification : Bacteria.
- drug effects : Microbial Consortia.
- isolation & purification : Bacteria.
- microbiology : Asthma, Respiratory System.
- pathogenicity : Bacteria.
- physiology : Microbiota.
- physiopathology : Asthma.
- Adult, Bronchial Hyperreactivity, Child, Drug Resistance, Bacterial, Humans, Microbial Interactions.
Abstract
This review summarizes the results of studies on the composition of microbial communities in the airways of healthy individuals and patients with asthma. Modern molecular genetic technology of the microbial identification, which are based on a sequence determination of encoding proteins genes conserved regions. These regions form the 16s-subunit ribosomal RNA in microorganisms of different species. These genes are detected by sequencing markers characteristic of individual microorganisms and their phylogenetic groups, and allow to perform a deep analysis of the microbiota in healthy volunteers and patients with chronic bronchoobstructive diseases. So, apparently healthy human bronchial tree is characterized by low bacterial contamination (most typical representatives here are the genera Pseudomonas, Streptococcus, Prevotella, Fusobacteria and Veilonella, much less potentially pathogenic Haemophilus and Neisseria are represented). In bronchial asthma patients the lower respiratory tract microbiota undergoes a qualitative transformation: as compared to healthy individuals the number of Proteobacteria increases and the number of Bacteroidetes decreases. Severe asthma in children is associated with significant respiratory tract Staphylococcus spp. insemination. Association between the asthma developing higher risk in young children and organisms such as Haemophilus, Moraxella and Neisseria spp. It is of considerable interest to determine the role of the microbiome in the development of human diseases of the bronchopulmonary system, and to understand the impact of the microbes communities as a course of disease and the important factor for the development of resistance to therapy.
DOI: 10.15690/vramn.v69i3-4.999
PubMed: 25306600
Affiliations:
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Kirillova</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25306600</idno><idno type="pmid">25306600</idno><idno type="doi">10.15690/vramn.v69i3-4.999</idno><idno type="wicri:Area/Main/Corpus">000191</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000191</idno><idno type="wicri:Area/Main/Curation">000191</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000191</idno><idno type="wicri:Area/Main/Exploration">000191</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[The airways microbial community composition in healthy individuals and bronchial asthma patients].</title><author><name sortKey="Fedosenko, S V" sort="Fedosenko, S V" uniqKey="Fedosenko S" first="S V" last="Fedosenko">S V Fedosenko</name></author><author><name sortKey="Ogorodova, L M" sort="Ogorodova, L M" uniqKey="Ogorodova L" first="L M" last="Ogorodova">L M Ogorodova</name></author><author><name sortKey="Karnaushkina, M A" sort="Karnaushkina, M A" uniqKey="Karnaushkina M" first="M A" last="Karnaushkina">M A Karnaushkina</name></author><author><name sortKey="Kulikov, E S" sort="Kulikov, E S" uniqKey="Kulikov E" first="E S" last="Kulikov">E S Kulikov</name></author><author><name sortKey="Deev, I A" sort="Deev, I A" uniqKey="Deev I" first="I A" last="Deev">I A Deev</name></author><author><name sortKey="Kirillova, N A" sort="Kirillova, N A" uniqKey="Kirillova N" first="N A" last="Kirillova">N A Kirillova</name></author></analytic><series><title level="j">Vestnik Rossiiskoi akademii meditsinskikh nauk</title><idno type="ISSN">0869-6047</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Asthma (microbiology)</term><term>Asthma 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microbiennes (MeSH)</term><term>Microbiote (physiologie)</term><term>Résistance bactérienne aux médicaments (MeSH)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Bacteria</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Microbial Consortia</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Consortiums microbiens</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Bacteria</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Bactéries</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Asthme</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Asthma</term><term>Respiratory System</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Bacteria</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Bactéries</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Microbiote</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Microbiota</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Asthme</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Asthma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Bronchial Hyperreactivity</term><term>Child</term><term>Drug Resistance, Bacterial</term><term>Humans</term><term>Microbial Interactions</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="fr"><term>Adulte</term><term>Bactéries</term><term>Enfant</term><term>Humains</term><term>Hyperréactivité bronchique</term><term>Interactions microbiennes</term><term>Résistance bactérienne aux médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This review summarizes the results of studies on the composition of microbial communities in the airways of healthy individuals and patients with asthma. Modern molecular genetic technology of the microbial identification, which are based on a sequence determination of encoding proteins genes conserved regions. These regions form the 16s-subunit ribosomal RNA in microorganisms of different species. These genes are detected by sequencing markers characteristic of individual microorganisms and their phylogenetic groups, and allow to perform a deep analysis of the microbiota in healthy volunteers and patients with chronic bronchoobstructive diseases. So, apparently healthy human bronchial tree is characterized by low bacterial contamination (most typical representatives here are the genera Pseudomonas, Streptococcus, Prevotella, Fusobacteria and Veilonella, much less potentially pathogenic Haemophilus and Neisseria are represented). In bronchial asthma patients the lower respiratory tract microbiota undergoes a qualitative transformation: as compared to healthy individuals the number of Proteobacteria increases and the number of Bacteroidetes decreases. Severe asthma in children is associated with significant respiratory tract Staphylococcus spp. insemination. Association between the asthma developing higher risk in young children and organisms such as Haemophilus, Moraxella and Neisseria spp. It is of considerable interest to determine the role of the microbiome in the development of human diseases of the bronchopulmonary system, and to understand the impact of the microbes communities as a course of disease and the important factor for the development of resistance to therapy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25306600</PMID><DateCompleted><Year>2014</Year><Month>12</Month><Day>17</Day></DateCompleted><DateRevised><Year>2019</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0869-6047</ISSN><JournalIssue CitedMedium="Print"><Issue>3-4</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>Vestnik Rossiiskoi akademii meditsinskikh nauk</Title><ISOAbbreviation>Vestn Ross Akad Med Nauk</ISOAbbreviation></Journal><ArticleTitle>[The airways microbial community composition in healthy individuals and bronchial asthma patients].</ArticleTitle><Pagination><MedlinePgn>71-6</MedlinePgn></Pagination><Abstract><AbstractText>This review summarizes the results of studies on the composition of microbial communities in the airways of healthy individuals and patients with asthma. Modern molecular genetic technology of the microbial identification, which are based on a sequence determination of encoding proteins genes conserved regions. These regions form the 16s-subunit ribosomal RNA in microorganisms of different species. These genes are detected by sequencing markers characteristic of individual microorganisms and their phylogenetic groups, and allow to perform a deep analysis of the microbiota in healthy volunteers and patients with chronic bronchoobstructive diseases. So, apparently healthy human bronchial tree is characterized by low bacterial contamination (most typical representatives here are the genera Pseudomonas, Streptococcus, Prevotella, Fusobacteria and Veilonella, much less potentially pathogenic Haemophilus and Neisseria are represented). In bronchial asthma patients the lower respiratory tract microbiota undergoes a qualitative transformation: as compared to healthy individuals the number of Proteobacteria increases and the number of Bacteroidetes decreases. Severe asthma in children is associated with significant respiratory tract Staphylococcus spp. insemination. Association between the asthma developing higher risk in young children and organisms such as Haemophilus, Moraxella and Neisseria spp. It is of considerable interest to determine the role of the microbiome in the development of human diseases of the bronchopulmonary system, and to understand the impact of the microbes communities as a course of disease and the important factor for the development of resistance to therapy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fedosenko</LastName><ForeName>S V</ForeName><Initials>SV</Initials></Author><Author ValidYN="Y"><LastName>Ogorodova</LastName><ForeName>L M</ForeName><Initials>LM</Initials></Author><Author ValidYN="Y"><LastName>Karnaushkina</LastName><ForeName>M A</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Kulikov</LastName><ForeName>E S</ForeName><Initials>ES</Initials></Author><Author ValidYN="Y"><LastName>Deev</LastName><ForeName>I A</ForeName><Initials>IA</Initials></Author><Author ValidYN="Y"><LastName>Kirillova</LastName><ForeName>N A</ForeName><Initials>NA</Initials></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Vestn Ross Akad Med Nauk</MedlineTA><NlmUniqueID>9215641</NlmUniqueID><ISSNLinking>0869-6047</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001249" MajorTopicYN="Y">Asthma</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001419" MajorTopicYN="Y">Bacteria</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016535" MajorTopicYN="Y">Bronchial Hyperreactivity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024881" MajorTopicYN="N">Drug Resistance, Bacterial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059013" MajorTopicYN="N">Microbial Consortia</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056265" MajorTopicYN="N">Microbial Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064307" MajorTopicYN="N">Microbiota</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012137" MajorTopicYN="N">Respiratory System</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>10</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>10</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25306600</ArticleId><ArticleId IdType="doi">10.15690/vramn.v69i3-4.999</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Deev, I A" sort="Deev, I A" uniqKey="Deev I" first="I A" last="Deev">I A Deev</name><name sortKey="Fedosenko, S V" sort="Fedosenko, S V" uniqKey="Fedosenko S" first="S V" last="Fedosenko">S V Fedosenko</name><name sortKey="Karnaushkina, M A" sort="Karnaushkina, M A" uniqKey="Karnaushkina M" first="M A" last="Karnaushkina">M A Karnaushkina</name><name sortKey="Kirillova, N A" sort="Kirillova, N A" uniqKey="Kirillova N" first="N A" last="Kirillova">N A Kirillova</name><name sortKey="Kulikov, E S" sort="Kulikov, E S" uniqKey="Kulikov E" first="E S" last="Kulikov">E S Kulikov</name><name sortKey="Ogorodova, L M" sort="Ogorodova, L M" uniqKey="Ogorodova L" first="L M" last="Ogorodova">L M Ogorodova</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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